Further Reading Resources

Authoritative Clinical Guidelines

Clinical guías are key references for physicians and a reliable source for pacientes to understand "what is standard practice." The following are issued by authoritative nefrología societies and reviewed via basado en evidencia medicine.

• KDIGO 2025 ADPKD Clinical Practice Guideline — Issued by KDIGO, the international nefrología authority. Covers diagnóstico, evaluation, estratificación de riesgo, and tratamiento. View guía ↗ Guideline
• Chinese ADPKD Diagnosis and Treatment Guideline (2024) — Issued by the Chinese Society of Nephrology, tailored to Chinese paciente characteristics. CMA ↗ Guideline
• ERA-EDTA ADPKD Guideline — Issued by the European Renal Association. ERA-EDTA ↗ Guideline
• RAAP Risk Stratification (2024) — ADPKD riesgo assessment tool to help judge disease progresión speed. View article ↗ Guideline

Authoritative Research Institutions and Academic Organizations

These institutions are leading authorities in ADPKD investigación, regularly publishing new findings and paciente education materials.

• KDIGO (Kidney Disease: Improving Global Outcomes) — International nefrología guía órganoization. kdigo.org ↗
• ERA-EDTA (European Renal Association) — Europe's largest nefrología academic órganoization. era-edta.org ↗
• ASN (American Society of Nephrology) — US nefrología academic authority. asn-online.org ↗
• ISN (International Society of Nephrology) — Global nefrología órganoization providing educational resources and guías. theisn.org ↗
• Chinese Society of Nephrology — Chinese nefrología academic órganoization. cma.org.cn ↗
• PKD Foundation (US) — Nonprofit dedicated to ADPKD investigación funding and paciente education. pkdfoundation.org ↗
• Mayo Clinic ADPKD Research Center — Mayo Clinic is a leading ADPKD investigación institution and originator of the TKV measurement method. Mayo Clinic ↗
• NIDDK (US National Institute of Diabetes and Digestive and Kidney Diseases) — NIH institute providing authoritative paciente education materials. NIDDK ↗

Patient Organizations and Support Groups

Patient órganoizations provide peer apoyo, latest investigación news, and advocacy. The following are internationally recognized ADPKD paciente órganoizations.

• PKD Foundation (US) — The world's largest ADPKD paciente órganoization, providing investigación funding, paciente education, and apoyo events. pkdfoundation.org ↗
• PKD Charity (UK) — UK ADPKD paciente charity providing paciente information and psychological apoyo. pkdcharity.org.uk ↗
• PKD Foundation of Canada — Canadian ADPKD paciente órganoization. endpkd.ca ↗
• European PKD Federation — European ADPKD paciente alliance uniting national órganoizations. pkdinternational.org ↗

Landmark Trials and Milestone Studies

The following papers are milestone estudios in ADPKD that have changed clínico practice. Links point to PubMed or journal originals; abstracts are freely accessible.

Tolvaptan

• TEMPO 3:4 Trial (2012) — Key RCT showing tolvaptán slows ADPKD progresión. NEJM. PubMed ↗ RCT
• TEMPO 4:4 Extension Trial (2017) — Long-term eficacia and seguridad of tolvaptán. Am J Kidney Dis. PubMed ↗ RCT
• REPRISE Trial (2017) — Tolvaptan eficacia in advanced ADPKD. Lancet. PubMed ↗ RCT

Disease Progression and Risk Factors

• CRISP Study Cohort — Longitudinal imaging estudio that established TKV growth rate as a prognostic indicator. J Am Soc Nephrol. PubMed ↗ Cohort
• Caffeine and Cyst Growth (2015) — Cellular and animal evidencia that cafeína stimulates quiste fluid secreción. J Am Soc Nephrol. PubMed ↗ Cell+Animal
• Salt Intake and ADPKD Progression — Protective effect of low-salt diet in ADPKD. Am J Kidney Dis. PubMed ↗ RCT

Blood Pressure Management

• HALT-PKD Study (2014) — Effect of ACEI/ARB dual blockade and strict presión arterial control in ADPKD. J Am Soc Nephrol. PubMed ↗ RCT
• ADPKD Blood Pressure Targets — Effect of strict presión arterial control (<110/75) on TKV and eGFR. JASN. PubMed ↗ RCT

Genetics and Inheritance

• PKD1/PKD2 Genotype-Phenotype Correlation — Relationship between mutación type and disease severity. J Am Soc Nephrol. PubMed ↗ Cohort
• ADPKD Genetic Counseling Guideline — Practice guía from the National Society of Genetic Counselors. J Genet Couns. PubMed ↗ Guideline

Imaging and Diagnosis

• Mayo TKV Classification System — Imaging classification for ADPKD estratificación de riesgo based on TKV growth rate. J Am Soc Nephrol. PubMed ↗ Cohort
• MRI in ADPKD — Standardized protocol for MRI-based TKV measurement. Radiology. PubMed ↗ Review

Patient Education Materials

The following resources are aimed at pacientes and families, explaining ADPKD in plain language. Suitable as introductory reading.

• NIDDK Patient Education — NIH ADPKD paciente guide, authoritative and accessible. NIDDK ↗
• Mayo Clinic Patient Information — ADPKD paciente education covering síntomas, diagnóstico, and tratamiento overview. Mayo Clinic ↗
• MedlinePlus ADPKD — US National Library of Medicine paciente information linking multiple reliable sources. MedlinePlus ↗
• NHS (UK) ADPKD Page — Patient information from the UK National Health Service. NHS ↗
• UpToDate Patient Education — Evidence-based paciente education articles (some content requires registration). UpToDate ↗

Literature Search Tools

If you want to search ADPKD literature yourself, these tools can help.

• PubMed — Free literature database from the US National Library of Medicine; search all medical literature abstracts. Search ADPKD ↗
• Cochrane Library — Systematic review database providing high-quality evidencia reviews (some free). Cochrane ↗
• ClinicalTrials.gov — Global ensayo clínico registry; find ongoing ADPKD trials. Search ADPKD trials ↗
• Google Scholar — Academic search engine; search full text (some require institutional access). Google Scholar ↗

How to Read a Medical Paper

If you are reading medical papers for the first time, the following tips may help.

• Read the abstract first — The abstract summarizes the estudio's purpose, methods, results, and conclusions; it's the best entry point for quick relevance assessment
• Note the estudio type — Evidence hierarchy from high to low: Systematic review > RCT > Cohort > Case-control > Case report > Expert opinion
• Check sample size — Larger samples yield more reliable results. Conclusions from estudios of dozens of people should be treated cautiously
• Pay attention to confidence intervals — A narrower 95% CI means a more precise estimate. If the CI crosses 1 (for odds ratios), the result may not be significant
• Distinguish correlation from causation — Observational estudios can only prove "association," not "causation"
• Check funding source — Industry-funded estudios may have conflicts of interest; note disclosure information
• Don't rely on a single paper — A single estudio's conclusion may be chance; multiple consistent estudios are more credible

Link Screening Criteria

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• Peer-reviewed — Paper links point to PubMed or journal originals, all revisado por pares sources
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